منابع مشابه
Molecular pH Probes: mediators of angina and ischemic preconditioning?
Physiology is an old (some today may consider it an ancient) discipline. However, physiology is, at its core, the discipline that merges structure and function in biological organisms. Over the past 30 years, as technology has advanced, the discipline has gravitated to smaller and smaller systems and structures, going from the whole body to the cell, to subcellular structures, and eventually en...
متن کاملMolecular fluorescent pH-probes based on 8-hydroxyquinoline.
Three 5,7-pi-extended 8-benzyloxyquinolines, namely 5,7-diphenyl-, 5,7-bis(biphenyl-4-yl)- and 5,7-bis(4-dibenzothiophenyl)-8-benzyloxyquinoline were prepared and investigated as fluorescent pH-probes in nonaqueous solution. Absorption and photoluminescence spectra of the introduced compounds also including the starting material 8-benzyloxy-5,7-dibromoquinoline as well as their N-protonated cou...
متن کاملStrategies for Developing pH Sensitive Fluorescent Probes
Many physiological processes function efficiently within a well-controlled pH range. Higher acidity level has been implicated with a number of systemic pathologies. The potential of pH sensitive fluorescent probes for reporting on biological environments has been widely utilized in a variety of cell studies and has been recently recognized as a powerful technique for in vivo imaging of diseases...
متن کاملSingle-cell intracellular nano-pH probes.
Within a large clonal population, such as cancerous tumor entities, cells are not identical, and the differences between intracellular pH levels of individual cells may be important indicators of heterogeneity that could be relevant in clinical practice, especially in personalized medicine. Therefore, the detection of the intracellular pH at the single-cell level is of great importance to ident...
متن کاملMolecular and Cellular Probes
Real-time PCR was used to analyze archived blood from non-human primates (NHP) and fluid samples originating from a well-controlled Q fever vaccine efficacy trial. The PCR targets were the IS1111 element and the com1 gene of Coxiella burnetii. Data from that previous study were used to evaluate real-time PCR as an alternative to the use of sero-conversion by mouse bioassay for both quantificati...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2006
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000241052.33145.54